| First in India | Name |
| First Nuclear Reactor in India | Apsara (Located in Maharashtra) |
| First Satellite of India | Aryabhatta |
| First woman to climb Mount Everest | Bachhendri Pal |
| First genetically modified food product in India | Bt. Eggplant Hybrid [Banned] |
| First Indian to get Nobel Prize in Physics | C.V Raman |
| First female mining engineer in India | Chandrani Prasad Verma |
| First moon mission of India | Chandrayan-1 (2008-2009) |
| First Indian to be appointed as the deputy director-general of programmes (DDP) of the World Health Organization (WHO) | Dr. Soumya Swaminathan |
| First Indian Pilot in India | J.R.D. Tata |
| First Temple constructed from a single rock | Kailasa Temple at Ellora |
| First Dam in India | Kallanai Dam |
| First woman to go to space from India | Kalpana Chawla |
| First female entrepreneur in India | Kalpana Saroj |
| First woman IPS officer in India | Kiran Bedi |
| First successful nuclear test in India | Operation Smiling Buddha, 18th May 1974 |
| First silent movie in India | Raja Harishchandra |
| First Indian in Space | Rakesh Sharma |
| First Space Shuttle launched in India | RLV-TD, 2016 |
| First Female Doctor in India | Rukhmabai Bhimrao Raut |
| First IAS officer of India | Satyendranath Tagore |
| First satellite earth station in India for domestic communications | Secunderabad |
| First Indian to develop an Airplane | Shivkar Bapuji Talpade |
| First Hydroelectric Plant | Sidrapong (Darjeeling) |
| First successful indigenous launch vehicle | SLV-3 |
| First to pass the Indian Medical Service (IMS) Examination | Surjo Kumar Chakroborty |
| First Nuclear Plant in India | Tarapur Atomic Power Plant-1 |
| First Newspaper in India | The Bengal Gazette, 1780 |
| First Computer developed in India | TIFRAC |
| First Hindi newspaper in India | Udant Martand (30 May 1826) |
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